Surveillance of hepatocellular carcinoma by medical imaging

Effective treatments for early-stage hepatocellular carcinoma (HCC) have provided the rationale for HCC surveillance since detection of the disease at an early stage is associated with more favorable outcome. In a prospective multi-institutional diagnostic study, Park et al. (1) evaluated the added value of (perfluorobutane) contrast-enhanced ultrasound (CEUS) when combined with conventional B-mode ultrasound (US) as an HCC surveillance tool in participants with liver cirrhosis using a single arm, intraindividual comparison study design.