A huge invasive ductal carcinoma of the left breast
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A huge invasive ductal carcinoma of the left breast

Yang Wang, Yi Ma, Bin Zhu

Department of Radiology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China

Corresponding to: Bin Zhu, MD. Department of Radiology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, No.321 Zhongshan Road, Nanjing 210008, China. Email: gobin10266@163.com.

Abstract: Breast cancer is the leading malignant tumors among women worldwide, the most common type of breast cancer being invasive ductal carcinoma. We report a case of huge invasive ductal carcinoma of the left breast in an 81-year-old woman.

Keywords: Breast cancer; invasive ductal carcinoma


Submitted Jun 08, 2013. Accepted for publication Jun 28, 2013.

doi: 10.3978/j.issn.2223-4292.2013.06.07


An 81-year-old woman presented with a huge mass of the left breast, with about the size of quail egg four years ago and enlarged gradually in the following years. Physical examination showed a large tumor, approximately 14 cm in maximal dimension, occupied the entire left breast without any pain or nipple discharge (Figure 1). Contrast-enhanced CT scanning revealed the tumor was heterogeneous with solid and cystic components and calcifications, and with uneven enhancement (Figure 2). There were no axillary nodes. The woman underwent modified radical mastectomy, microscopic examination confirmed the diagnosis of an invasive ductal carcinoma (T4aN0M0, Stage IIIA), associated with large areas of necrosis and cystic component, and involved the subcutaneous tissue (Figure 3). Further immunohistochemical examination showed the lesion was ER(-), PR(-), C-erbB-2(+++), P53(-) and the positivity of cell proliferation marker Ki67 was less than 20%. The patient recovered well after operation with adjuvant therapy and she remained free from recurrence after 6 months of clinical observation. Invasive ductal carcinoma is the major type of breast malignancy, usually occurred in premenopausal woman. The combination of surgical resection and the adjuvant therapy such as endocrine therapy or chemotherapy remain the main treatment method.

Figure 1 Gross examination showed a 14 cm × 11 cm × 8 cm mass occupied nearly the entire left breast
Figure 2 Axial enhanced chest CT image reveals a solid and cystic mass with calcification (arrow) and ill defined border
Figure 3 Pathological results (H&E stain ×100) demonstrate large areas of necrosis and cystic degeneration (arrow)

Acknowledgements

Disclosure: The authors declare no conflict of interest.

Cite this article as: Yang Wang Y, Ma Y, Zhu B. A huge invasive ductal carcinoma of the left breast. Quant Imaging Med Surg 2013;3(3):182-183. doi: 10.3978/j.issn.2223-4292.2013.06.07

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