Comparison of chest computed tomography in Turbo FLASH mode with conventional mode for coronary artery disease screening: radiation dose, image quality, and calcium scoring performance
Introduction
Coronary artery disease (CAD) is the primary cause of premature mortality, significantly burdening the global healthcare system (1,2). Coronary artery calcium (CAC), as a marker and an early indicator of CAD (3), is typically quantified via the coronary artery calcification score (CACS) (4). Clinically, CACS is obtained through a non-enhanced coronary calcium scan (CCS) (5-7), which is often conducted alongside coronary computed tomography (CT) angiography to provide a comprehensive assessment of cardiovascular stenosis and calcification, rather than as a standalone procedure. The complexity and high cost of these exams, coupled with the prolonged asymptomatic phase of CAD (7), frequently result in delayed CAC measurements for patients.
Utilizing routine non-gated chest CT scans for CACS quantification offers a potential solution to these challenges, avoiding additional radiation exposure and economic burden, especially in the context of widespread low-dose CT lung cancer screening programs. However, the accuracy of CACS assessment using chest CT is still debated, with previous meta-analyses reporting significant false-negative rates (8.8%) (8), mainly due to the inability to suppress coronary motion artifacts. However, with advances in CT technology, improving the temporal resolution of chest CT may be a potentially feasible solution (9-13).
The ultra-fast Turbo FLASH mode of dual-source CT (DSCT), which employs two X-ray tubes and detectors, stands out as the optimal choice for temporal resolution and has demonstrated highly consistent CACS results between chest CT (FLASH) and CCS (12,13). However, previous studies (12,13) have primarily compared the performance of CACS between chest CT (FLASH) and CCS, rarely including a conventional chest CT group for comparison. Although the faster scan mode helps reduce motion artifacts and radiation exposure (14), it may also compromise image resolution and increase quantum noise (15,16). Therefore, a comprehensive assessment of the advantages and disadvantages of this technology is essential.
In this study, we aimed to address these knowledge gaps by analyzing data from chest CT (FLASH) and chest CT (conventional) acquired on DSCT systems. Our primary objectives were to compare the radiation dose and image quality between the two modes, as well as evaluate their performance in CACS quantification and risk stratification. By highlighting the incremental value of the Turbo FLASH mode in chest CT for CAD screening, our findings contribute to improving the accuracy of CACS assessment in a dual-risk screening setting. We present this article in accordance with the STROBE reporting checklist (available at https://qims.amegroups.com/article/view/10.21037/qims-24-1005/rc).
Methods
Study sample
This retrospective study was approved by the Ethics Committee of the Second Affiliated Hospital of Chongqing Medical University (No. 2022-10) and was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The requirement for written informed consent was waived by the Ethics Committee due to the nature of the retrospective design.
We recruited patients who underwent clinically indicated routine chest CT and cardiac CT examinations (CCS and coronary CT angiography) during the same examination period at the Second Affiliated Hospital of Chongqing Medical University between January 2022 and March 2023. These chest CT scans were performed to evaluate chest-related diseases, for health screenings, and for other clinical reasons. Cardiac CTs were conducted in patients with a history of chest pain to assess potential CAD, as well as for follow-up in those with known CAD. Patients were excluded from the study based on the following criteria: (I) a history of percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), or metal implantation; (II) chest CT exams that included adjacent body parts, making it impossible to independently calculate the radiation dose for the chest CT. A radiologist accessed patient information using the Hospital Information System (Figure 1). Ultimately, a total of 968 patients were reviewed, comprising 493 in the chest CT (FLASH) group and 475 in the chest CT (conventional) group based on the different CT modalities.

CT acquisition
All imaging data were acquired from two DSCT systems (Somatom Force and Somatom Drive; Siemens Healthcare, Erlangen, Germany). The chest CT scans covered the entire lung volume, extending from the upper thoracic apex to the inferior margin of the diaphragm. The CCS comprehensively encompassed the heart, extending from 1 cm below the tracheal bifurcation to the diaphragmatic surface. Scanning parameters for chest CT (FLASH), chest CT (conventional), and CCS performed on these two CT systems are detailed in Table 1. The dose-length product (DLP) values for both chest CT and CCS were obtained from individual dose reports within the picture archiving and communication system (PACS).
Table 1
Index | Chest CT (FLASH) | Chest CT (conventional) | CCS | |||||
---|---|---|---|---|---|---|---|---|
Drive | Force | Drive | Force | Drive | Force | |||
Tube voltage (kV) | 120 | 120 | 120 | 120 | 120 | 120 | ||
Tube current (mAs) | CARE Dose4 (Ref. 250) |
CARE Dose4 (Ref. 150) |
CARE Dose4 (Ref. 150) |
CARE Dose4 (Ref. 80) |
CARE Dose4 (Ref. 80) |
CARE Dose4 (Ref. 80) |
||
Rotation time (s/rot) | 0.28 | 0.25 | 0.5 | 0.5 | 0.28 | 0.25 | ||
Pitch | 2.7 | 2.7 | 1.2 | 1.2 | * | * | ||
Scan field of view (cm) | 33.2 | 38.6 | 50 | 50 | * | * | ||
Collimation (mm) | 2×128×0.6 | 2×192×0.6 | 128×0.6 | 192×0.6 | 128×0.6 | 192×0.6 | ||
Slice thickness (mm) | 1 | 1 | 1 | 1 | 3 | 3 | ||
Slice increment (mm) | 0.7 | 0.7 | 1 | 1 | 1.5 | 1.5 | ||
Iterative reconstruction | ADMIRE3 | ADMIRE4 | ADMIRE3 | ADMIRE4 | FBP | FBP | ||
Convolution algorithm | Br37 | Bf40 | Bf38 | Bf40 | Qr36 | Qr36 | ||
Scanned phase of the cardiac cycle (R-R interval) | – | – | – | – | 70% (HR <75 bmp), 40% (HR ≥75 bpm) | 70% (HR <75 bmp), 40% (HR ≥75 bpm) |
*, changes as heart rate fluctuates. CT, computed tomography; CCS, coronary calcium scan; CARE Dose4, automatic tube current modulation; Ref., reference; ADMIRE, advanced modeled iterative reconstruction algorithm; FBP, filtered back projection; HR, heart rate.
CT image reconstruction and analysis
For all image analyses, the reconstructed series of chest CT [with harmonized parameters, including a slice thickness of 1 mm and an increment of 0.7 mm for chest (FLASH) and both a slice thickness and increment of 1 mm for chest (conventional)] and CCS (with a slice thickness of 3 mm and an increment of 1.5 mm) were transferred to a Siemens syngo MMWP VE36A workstation. Image quality was assessed through a combined subjective and objective evaluation. Two radiologists, each with over five years of experience in cardiac imaging, conducted all image analyses and measurements collaboratively. In cases of discrepancies or differing opinions, the radiologists held additional consultations to reach a consensus.
Chest CT images analysis
Based the 1975 American Heart Association coronary classification, the coronary arteries in chest CT images were segmented into 18 sections for subjective evaluation (17,18). A scoring system was employed to rate coronary artery segments with diameters exceeding 1.5 mm, according to the following criteria: 1 (excellent): no artifacts, with ≥14 segments; 2 (good): 9–13 segments; 3 (moderate): 4–8 segments; 4 (bad): <4 segments.
The evaluation of general chest CT images incorporated both subjective and objective assessments (Figure 2). Subjectively, the fine structure was assessed using a 3-point scale based on lung window settings (window width 1,200; window center −600), as follows:
- Score of “1”: slightly blurred structure with artifacts in the lung texture and field, but still diagnostic;
- Score of “2”: fine structure with good contrast, slight artifacts, and some blurring of lung texture;
- Score of “3”: clear display of fine structure with excellent contrast, sharp edges, and detailed lung texture.

For the objective evaluation, mediastinum window settings (window width 400; window center 40) were utilized to measure signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). At the four-chambered cardiac slice of the chest CT, three regions of interest (ROIs, 100 mm2) were positioned within the mediastinum, and another three ROIs (20–30 mm2) were placed within subcutaneous fat. The mean CT number (Hounsfield units, HU) from the three mediastinal ROIs was denoted as HUsofttissue, and its standard deviation (SD) was labeled as SDsoft tissue. The mean CT number from the three fat ROIs was defined as HUfat, and its SD was referred to as SDbackground. SNR and CNR were then calculated using the following formulas:
CACS quantitation and risk category analysis
The calcified areas (CT number ≥130 HU, area ≥1 mm2) within each coronary artery segment were identified and labeled using the workstation, contributing to the overall CACS (4). Based on the total CACS, five risk categories were established: category 0 (CACS 0, no or very low risk), category 1 (CACS 1–10, low risk), category 2 (CACS 11–100, mild risk), category 3 (CACS 101–400, moderate risk), and category 4 (CACS >400, severe risk) (19).
Statistical analysis
The statistical analyses were performed using the software SPSS 26.0 (IBM Corp., Armonk, NY, USA) and MedCalc Version 20.2 (MedCalc, Ostend, Belgium). Continuous data were analyzed for normal distribution using the Shapiro-Wilk test. Data that followed a normal distribution were presented as mean and standard deviation (mean ± SD) and compared between groups using the independent samples t-test. Skewed data were expressed as medians with interquartile ranges (IQRs), and group comparisons were made using the Mann-Whitney U test. Categorical variables were reported as frequencies and analyzed among groups using the chi-square test or Fisher’s exact test. A significance level of P<0.05 was considered statistically significant. The correlation of CACS between CCS and chest CT (FLASH) or chest CT (conventional) was determined using the Spearman correlation coefficient. Bland-Altman plots were used to present bias and limits of agreement within the 95% confidence interval. Kappa analysis was performed to assess agreement in risk categorization between two sets of data.
Results
Demographics and clinical characteristics
No significant difference was observed in clinical characteristics and traditional CAD risk factors between chest CT (FLASH) set and chest CT (conventional) set (Table 2).
Table 2
Clinical characteristics | FLASH (n=493) | Conventional (n=475) | χ2/Z value | P value |
---|---|---|---|---|
Gender | 0.001† | 0.977 | ||
Male | 262 (53.1) | 252 (53.1) | ||
Female | 231 (46.9) | 223 (46.9) | ||
Age (years) | 60 [54–69] | 60 [53–69] | −0.071‡ | 0.943 |
Heart rate (beats per minute) | 68 [57–79] | 69 [60–80] | −1.541‡ | 0.123 |
Body mass index (kg/m2) | 21.1 [19.1–23.2] | 20.7 [18.71–23.01] | −1.38‡ | 0.168 |
Smoking | 183 (37.12) | 188 (39.58) | 0.618† | 0.432 |
Drinking | 191 (38.74) | 179 (37.68) | 0.115† | 0.735 |
Hypertension | 236 (47.87) | 249 (52.42) | 1.793† | 0.181 |
Diabetes | 154 (31.24) | 175 (36.84) | 3.384† | 0.066 |
Hyperlipidemia | 260 (52.74) | 238 (50.11) | 0.671† | 0.413 |
Data are presented as n (%) or median [IQR]. †, Chi-squared test; ‡, Mann-Whitney U test; IQR, interquartile range.
Radiation dose and image quality assessment
The median radiation dose for CCS was 114.1 (IQR, 84.75–158.3) mGy·cm. In comparison, chest CT scans had more than double this dose: 281.4 (IQR, 248.85–319.5) mGy·cm for FLASH mode and 304.6 (IQR, 246.45–381.6) mGy·cm for conventional mode. Among the enrolled patients, 74.2% (366/493) demonstrated good coronary artery quality (scoring 1 or 2) in the chest CT (FLASH) set, whereas this value was only 15.4% (73/475) in the chest CT (conventional) set. To visually compare coronary images between chest CT (FLASH), chest CT (conventional), and CCS (Figure 3), we searched among 968 participants and found 17 who underwent three CT exams within three months. The FLASH mode did manage to prevent motion artifact caused by failure breath-holding while achieving superior fine structure scores in the chest CT (FLASH) set (P<0.05). The CNR was not statically significant between chest CT (FLASH) set and chest CT (conventional) set (P=0.708). Nevertheless, SNR in chest CT (FLASH) was slightly inferior than that in chest CT (conventional) (median SNR 21.02 vs. 25.54; P<0.05) (Table 3).

Table 3
Parameters | FLASH (n=493) | Conventional (n=475) | χ2/Z/t value | P value |
---|---|---|---|---|
DLP (mGy·cm) | 281.4 [248.85–319.5] | 304.6 [246.45–381.6] | −4.556† | <0.001 |
Coronary artery quality | ||||
1 | 186 (37.7) | 5 (1.1) | 205.242‡ | <0.001 |
2 | 180 (36.5) | 68 (14.3) | 62.475‡ | <0.001 |
3 | 102 (20.7) | 170 (35.8) | 26.577‡ | <0.001 |
4 | 25 (5.1) | 232 (48.8) | 237.432‡ | <0.001 |
Fine structure | 2.98±0.15 | 2.91±0.29 | −4.594§ | <0.001 |
SNR | 21.02 [12.17–29.87] | 25.54 [12.92–38.17] | −2.708† | 0.007 |
CNR | 52.38 [29.15–75.6] | 55.55 [27.6–83.49] | −0.374† | 0.708 |
Data are presented as median [IQR], n (%) or mean ± SD. Fine structure using 3-point Likert scale (1, the structure was slightly blurred with artifacts in the lung texture and lung field, but the image could be used for diagnosis; 2, fine structure with good contrast, slight artifacts, and blur of lung texture; 3, clear display of fine structure with excellent contrast, sharp and clear edges of lung texture). †, Mann-Whitney U test; ‡, Chi-squared test; §, independent samples t-test. CT, computed tomography; DLP, dose-length product; SNR, signal-to-noise ratio; CNR, contrast-to-noise ratio; IQR, interquartile range; SD, standard deviation.
Quantification of CACS
The false negatives in chest CT (conventional) set outnumbered those in chest CT (FLASH) set at 22 cases versus five cases. Spearman’s rank correlation coefficient was used to determine the correlation of CACS between chest CT and CCS, yielding r=0.998 (P<0.05) for the chest CT (FLASH) set and r=0.941 (P<0.05) for the chest CT (conventional) set (Figure 4). The Bland-Altman plot (CACS of chest CT minus CCA-CACS) revealed a mean difference of −5.653 and 95% limits of agreement of −52.144 to 40.839 in the chest CT (FLASH) set, whereas the results had a mean difference of 7.142 and 95% limits of agreement of −247.678 to 261.962 in the chest CT (conventional) set (Figure 4).

Risk categorization
The risk categorization between CCS-CACS and the CACS of chest CT (the FLASH set and the conventional set) is shown in the confusion matrices in Table 4. Analysis of the weighted kappa results revealed a higher level of consistency in risk category for the chest CT (FLASH) set (κ=0.929) compared to the chest CT (conventional) set (κ=0.874). In terms of misclassification, there were 43 (8.7%) reported cases in the chest CT (FLASH) set and 76 cases (16%) in the chest CT (conventional) set.
Table 4
Chest CT categories |
CCS categories (ref.) | Total | Underestimation | Overestimation | Concordance | ||||
---|---|---|---|---|---|---|---|---|---|
0 | 1 | 2 | 3 | 4 | |||||
FLASH | |||||||||
0 | 264 | 5 | 0 | 0 | 0 | 269 | 5 (1.9) | – | 264 (98.1) |
1 | 5 | 51 | 9 | 0 | 0 | 65 | 9 (13.8) | 5 (7.7) | 51 (78.5) |
2 | 0 | 7 | 76 | 9 | 0 | 92 | 9 (9.8) | 7 (7.6) | 76 (82.6) |
3 | 0 | 0 | 2 | 48 | 5 | 55 | 5 (9.1) | 2 (3.6) | 48 (87.3) |
4 | 0 | 0 | 0 | 1 | 11 | 12 | – | 1 (8.3) | 11 (91.7) |
Total | 269 | 63 | 87 | 58 | 16 | 493 | 28 (5.7) | 15 (3.0) | 450 (91.3) |
Conventional | |||||||||
0 | 270 | 19 | 3 | 0 | 0 | 292 | 22 (7.5) | – | 270 (92.5) |
1 | 4 | 23 | 16 | 0 | 0 | 43 | 16 (37.2) | 4 (9.3) | 23 (53.5) |
2 | 0 | 8 | 45 | 9 | 0 | 62 | 9 (14.5) | 8 (12.9) | 45 (72.6) |
3 | 0 | 0 | 10 | 29 | 5 | 44 | 5 (11.4) | 10 (22.7) | 29 (65.9) |
4 | 0 | 0 | 0 | 2 | 32 | 34 | – | 2 (5.9) | 32 (94.1) |
Total | 274 | 50 | 74 | 40 | 37 | 475 | 52 (10.9) | 24 (5.1) | 399 (84.0) |
Values are n or n (%). Category 0, CACS 0; Category 1, CACS 1–10; Category 2, CACS 11–100; Category 3, CACS 101–400; Category 4: CACS >400. CT, computed tomography; CCS, coronary calcium scan; Ref., reference; CACS, coronary artery calcification score.
Discussion
To enable chest CT for dual-risk screening (lung cancer and CAD), the optimization of scanning protocol should be considered comprehensively. This encompasses factors such as radiation dose, image quality for both lung and coronary, and performance on CACS.
Radiation dose reduction and image quality impact
In CT scans, radiation dose is influenced by various factors, including protocols, scanning parameters, scan duration, and patient sample size (20-22). Consequently, studies have shown a wide range of DLP values, from the low tens to over 600 mGy·cm for chest CT (12,13,23-27), and DLP typically remains below 50 mGy·cm for cardiac CT (13,28,29). Our results indicated relatively high radiation dose levels for both the heart with 114.1 (IQR, 84.75–158.3) mGy·cm and chest with 281.4 (IQR, 248.85–319.5) mGy·cm. We reasonably speculate that this elevation was caused by high tube current settings of 80 mAs or more in our CT protocols, compared to the typical range of 20–60 mAs used in low-dose protocols (12,13). The high reference mAs setting might enhance image quality, especially for patients with cardiovascular and pulmonary histories. Additionally, for chest CT, over scanning was noted in patients who had difficulty holding their breath, and some were unable to raise their arms, resulting in increased automatic tube current exposure (30).
FLASH mode is Siemens’ unique dual-tube, dual-detector ultra-fast CT scanning technology. Our study demonstrated an 11.1% (36.47 mGy·cm) reduction in radiation dose with chest CT using FLASH mode. However, doses remained high due to the reference mAs settings. This can be addressed through the optimization of scanning parameters. In a low-dose protocol utilizing an ultra-low reference mAs of 20 for FLASH mode, it achieved a DLP of only 58.7±18.4 mGy·cm for chest CT (13).
Further reduction in radiation dose can be achieved through various reconstruction techniques. The system can be optimized by integrating advanced methods, such as deep learning algorithms and precise scanning positioning technologies. Deep learning image reconstruction (DLIR) has been reported to reduce doses by 50% or more while maintaining image quality (24,31-33). Additionally, three-dimensional (3D) landmark scanning technology can minimize over scanning by accurately targeting organs, potentially decreasing scan length by 12.7 mm and reducing radiation dose by 11.9% for chest CT scans (23).
Moreover, the ultra-high temporal resolution of the Turbo FLASH mode effectively mitigates motion artifacts in both lung parenchyma and coronary arteries, a longstanding limitation of non-gated chest CT for CAD screening (8). Although the Turbo FLASH mode excels in motion artifact suppression, it is crucial to assess its potential impact on image quality. Consistent with a previous report (34), our objective evaluation revealed a slight decrease in SNR in the chest CT (FLASH) dataset. However, it is noteworthy that no significant deterioration was observed in the CNR. This discrepancy can be attributed to the differing tissue types used for noise calculation, where soft tissue is employed for SNR and subcutaneous fat for CNR. The lower attenuation of subcutaneous fat renders it less prone to artifacts or increased noise induced by high pitch values (35).
CACS quantification
The accurate quantification of CACS and the subsequent risk stratification based on CACS thresholds are pivotal components in the comprehensive evaluation and management of cardiovascular disease risk. In this part, we focused on assessing the performance of the Turbo FLASH mode in chest CT for CACS quantification and risk categorization, in comparison to the conventional chest CT mode.
Unlike the interval scanning (36,37), our participants had undergone chest CT and CCS scans in the same examination, thus eliminating the potential impact of CACS changes over time. Regarding CACS quantification, the chest CT (FLASH) set demonstrated superior performance compared to the chest CT (conventional) in terms of linear correlation (r, 0.998 vs. 0.941) and consistency [mean difference −5.653 vs. 7.142; 95% limits of agreement (−52.144 to 40.839) vs. (−247.678 to 261.962)]. This robust correlation and high consistency underscore the reliability and accuracy of the Turbo FLASH mode in quantifying coronary artery calcifications.
Risk categorization
The primary aim of accurately quantifying CACS in chest CT is to facilitate risk categorization CAD. In our study, we classified the degree of calcification into five categories based on the total CACS. Overall, the Turbo FLASH mode displayed a superior concordance rate in risk categorization using CACS thresholds compared to the conventional mode (91.3% vs. 84%).
Across each specific category, the Turbo FLASH mode demonstrated remarkable consistency in risk classification. For category 0 (CACS 0), representing the absence of coronary calcification, the concordance rate was 98.1% (264/269) for the Turbo FLASH set and 92.5% (270/292) for the conventional set. This consistency in category 0 is paramount in evaluating the performance of CAC screening exams, as CACS 0 serves as a crucial cut-off point for initiating primary prevention measures (38). Furthermore, the Turbo FLASH mode showed the most significant improvement in the concordance rate for category 1 (CACS 1–10), which comprises microcalcifications that are often challenging to diagnose accurately in clinical settings. Specifically, the Turbo FLASH set achieved a concordance rate of 78.5% (51/65), whereas the conventional set only achieved 53.5% (23/43). Additionally, the Turbo FLASH mode maintained its superiority in the concordance rate for categories 2 (CACS 11–100) and 3 (CACS 101–400), achieving 82.6% (76/92) and 87.3% (48/55) respectively, compared to 72.6% (45/62) and 65.9% (29/44) for the conventional set. However, in category 4 (CACS >400), representing severe coronary calcification, the concordance rates between the two CT sets were similar, with a slight decrease in the Turbo FLASH set [91.7% (11/12) vs. 94.1% (32/34)]. Nevertheless, this similarity could be attributed to the small sample size in category 4, with only a few misclassified cases in each group.
In summary, our study demonstrated that the Turbo FLASH mode outperforms the conventional chest CT in the consistency of risk classifications from category 0 to 3, covering the range from no calcification to moderate CACS. This improved consistency in risk categorization is crucial for guiding clinical decision-making and implementing appropriate preventive measures in individuals with varying degrees of coronary artery calcification (6,39).
Analysis of risk categorization error cases
The chest CT (FLASH) set exhibited a significantly lower number of misclassification cases (43/493, 8.7% vs. 76/475, 16%) compared to the chest CT (conventional) set. These cases were wrongly assigned into adjacent risk categories in the chest CT (FLASH) set, whereas in the chest CT (conventional) set, three cases (3/475, 0.6%) were misclassified across groups, specifically from category 2 [11–100] to category 0 (CACS 0). The accuracy of risk category assignments is crucial as it directly impacts the intensity of risk management strategies (38), and thus, misclassification across groups may have more severe adverse effects on patients.
Furthermore, our results indicate that the majority of misclassified cases were underestimated, regardless of whether the FLASH mode (28/43, 65.1%) or the conventional mode (52/76, 68.4%) was used. Among these, five false negatives (1%) were observed in the chest CT (FLASH) set, and 22 false negatives (4.6%) in the chest CT (conventional) set. Notably, these false negatives had fairly low CACS values (2.46±4.08) and were accompanied by significant motion artifacts surrounding calcified plaques. These artifacts led to blurring of microcalcifications, ultimately resulting in reduced density and failure to recognize calcification, as exemplified in case 3 of Figure 3. Consequently, the chest CT (FLASH) modality can effectively reduce the false-negative rate (from 4.6% to 1%) by suppressing coronary motion artifacts.
The remaining misclassified cases were overrated, comprising 15 in the chest CT (FLASH) set and 24 in the chest CT (conventional) set. Of these, 83.3% (20/24) were non-zero CACS cases with relatively high CACS values (68.63±81.58) and severe motion artifacts. These artifacts contributed to an increase in the apparent volume of macrocalcification, as illustrated in Figure 3, case 2. In sum, motion artifact is the primary cause of misclassification, and the CT (FLASH) modality can significantly enhance the detection of microcalcifications and mitigate the occurrence of false negatives.
This study has several limitations that must be acknowledged. Firstly, since the two chest CT modes were performed separately, the results may be influenced by potential individual differences among the participants. However, we conducted a comparative analysis of the clinical characteristics between the two chest CT sets and found no statistically significant differences. Secondly, the limited number of cases with CACS >400 in this study necessitates the expansion of the sample size in future follow-up research to enhance the accuracy of the experimental results. Thirdly, the retrospective nature of the study limited our ability to compare radiation dose and image quality across different pitches, advanced post-processing reconstruction techniques, and precise scanning positioning technologies. This aspect will be further explored and incorporated in subsequent studies.
Conclusions
The utilization of Turbo FLASH mode in DSCT for the assessment of CACS in chest CT images emerges as a promising technical strategy, offering three distinct advantages. Firstly, it effectively reduces radiation dose and mitigates motion artifacts. Secondly, it significantly decreases the false-negative rate for coronary calcium screening. Lastly, chest CT using Turbo FLASH mode demonstrates superior performance in risk stratification especially for individuals with microcalcifications. Notably, excessive pitch can reduce SNR of the chest CT images. Therefore, it is crucial to strike a balance between image quality and clinical requirements when setting scan parameters.
Acknowledgments
This work was supported by all the reviewers who participated in the review and MJEditor (www.mjeditor.com) for its linguistic assistance during the preparation of this manuscript.
Footnote
Reporting Checklist: The authors have completed the STROBE reporting checklist. Available at https://qims.amegroups.com/article/view/10.21037/qims-24-1005/rc
Funding: This work was supported by
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://qims.amegroups.com/article/view/10.21037/qims-24-1005/coif). The authors have no conflicts of interest to declare.
Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. This retrospective study was approved by the Ethics Committee of the Second Affiliated Hospital of Chongqing Medical University (No. 2022-10) and was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The requirement for written informed consent was waived by the ethics committee due to the nature of the retrospective design.
Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
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