@article{QIMS8537,
author = {Romaric Loffroy and Béatrice Terriat and Valérie Jooste and Isabelle Robin and Marie-Claude Brindisi and Patrick Hillon and Bruno Vergès and Jean-Pierre Cercueil and Jean-Michel Petit},
title = {Liver fat content is negatively associated with atherosclerotic carotid plaque in type 2 diabetic patients},
journal = {Quantitative Imaging in Medicine and Surgery},
volume = {5},
number = {6},
year = {2015},
keywords = {},
abstract = {Background: Nonalcoholic fatty liver disease (NAFLD) is independently associated with atherosclerosis in nondiabetic individuals. In type 2 diabetic patients, the link between fatty liver and atherosclerosis is less clear. Here, we assessed whether liver fat content evaluated using 1H-magnetic resonance spectroscopy (1H-MRS) was independently associated with prevalent carotid plaque as a marker of atherosclerosis in type 2 diabetic patients.
Methods: One hundred and forty-four prospectively enrolled patients with type 2 diabetes underwent liver fat content measurement using 1H-MRS and carotid plaque assessment using ultrasound. Multiple logistic regressions were used to identify factors associated with carotid plaque.
Results: Mean ± SD liver fat content was 9.86±8.12%. Carotid plaque prevalence was 52.1% (75/144). Patients without plaque were younger (P=0.006) and had a smaller visceral fat area (P=0.015), lower reported prevalence of previous cardiovascular events or current statin therapy (P=0.002), and higher liver fat content than those with plaque (P=0.009). By multivariable logistic regression, increased liver fat content independently predicted the absence of carotid plaque [odds ratios (ORs), 0.94; 95% confidence intervals (CIs), 0.89-0.99; P=0.017].
Conclusions: Liver fat content measured by 1H-MRS is higher in type 2 diabetic patients without carotid plaque compared to those with plaque. This study suggests that increased liver fat content could be associated with a relative protection against carotid atherosclerosis in patients with type 2 diabetes mellitus.},
issn = {2223-4306}, url = {https://qims.amegroups.org/article/view/8537}
}