@article{QIMS668,
author = {Marybeth A. Pysz and Ismayil Guracar and Lu Tian and Jürgen K. Willmann},
title = {Fast microbubble dwell-time based ultrasonic molecular imaging approach for quantification and monitoring of angiogenesis in cancer},
journal = {Quantitative Imaging in Medicine and Surgery},
volume = {2},
number = {2},
year = {2012},
keywords = {},
abstract = {Purpose: To develop and test a fast ultrasonic molecular imaging technique for quantification and monitoring of angiogenesis in cancer.
Materials and methods: A new software algorithm measuring the dwell time of contrast microbubbles in near real-time (henceforth, fast method) was developed and integrated in a clinical ultrasound system. In vivo quantification and monitoring of tumor angiogenesis during anti-VEGF antibody therapy was performed in human colon cancer xenografts in mice (n=20) using the new fast method following administration of vascular endothelial growth factor receptor 2 (VEGFR2)-targeted contrast microbubbles. Imaging results were compared with a traditional destruction/replenishment approach (henceforth, traditional method) in an intra-animal comparison.
Results: There was excellent correlation (R2=0.93; P},
issn = {2223-4306}, url = {https://qims.amegroups.org/article/view/668}
}