@article{QIMS5966,
author = {Gopesh Patel and Martin Haas and Niravkumar Darji and Oliver Speck},
title = {Evaluation of 2D spatially selective MR spectroscopy using parallel excitation at 7 T},
journal = {Quantitative Imaging in Medicine and Surgery},
volume = {5},
number = {3},
year = {2015},
keywords = {},
abstract = {Background: In this work, two-dimensional spatially selective magnetic resonance spectroscopy (2D selective MRS) was evaluated in both phantom and human brain using 8-channel parallel excitation (pTX) at 7 T and compared to standard STEAM.
Materials and methods: A 2D spiral excitation k-space trajectory was segmented into multiple individual segments to increase the bandwidth. pTX was used to decrease the number of segments by accelerating the trajectory. Different radio frequency (RF) shim settings were used for refocusing, water suppression and fat saturation pulses.
Results: Phantom experiments demonstrate that, although segmented 2D excitation provided excellent spatial selectivity and spectral quality, STEAM outperformed it in terms of outer volume suppression with 0.6% RMSD compared to 1.7%, 2.5%, 3.9% and 5.5% RMSDs for acceleration factors of R=1, 2, 3 and 4, respectively. Seven major metabolites [choline (Cho), creatine (Cr), phosphocreatine (PCr), glutamate (Glu), glutamine (Gln), glutathione (GSH) and N-acetylaspartate (NAA)] were detected with sufficient accuracy [Cramér-Rao lower bounds (CRLBs) },
issn = {2223-4306}, url = {https://qims.amegroups.org/article/view/5966}
}