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Kinetic and perfusion modeling of hyperpolarized 13C pyruvate and urea in cancer with arbitrary RF flip angles

   
@article{QIMS3435,
	author = {Naeim Bahrami and Christine Leon Swisher and Cornelius Von Morze and Daniel B. Vigneron and Peder E. Z. Larson},
	title = {Kinetic and perfusion modeling of hyperpolarized 13C pyruvate and urea in cancer with arbitrary RF flip angles},
	journal = {Quantitative Imaging in Medicine and Surgery},
	volume = {4},
	number = {1},
	year = {2014},
	keywords = {},
	abstract = {The accurate detection and characterization of cancerous tissue is still a major problem for the clinical management of individual cancer patients and for monitoring their response to therapy. MRI with hyperpolarized agents is a promising technique for cancer characterization because it can non-invasively provide a local assessment of the tissue metabolic profile. In this work, we measured the kinetics of hyperpolarized [1-13C] pyruvate and 13C-urea in prostate and liver tumor models using a compressed sensing dynamic MRSI method. A kinetic model fitting method was developed that incorporated arbitrary RF flip angle excitation and measured a pyruvate to lactate conversion rate, Kpl, of 0.050 and 0.052 (1/s) in prostate and liver tumors, respectively, which was significantly higher than Kpl in healthy tissues [Kpl =0.028 (1/s), P},
	issn = {2223-4306},	url = {https://qims.amegroups.org/article/view/3435}
}