@article{QIMS33175,
author = {Lingling Cui and Fei Wang and Zhiyang Yin and Miao Chang and Yanzhuo Song and Yange Wei and Jing Lv and Yifan Zhang and Yanqing Tang and Xiaohong Gong and Ke Xu},
title = {Effects of the LHPP gene polymorphism on the functional and structural changes of gray matter in major depressive disorder},
journal = {Quantitative Imaging in Medicine and Surgery},
volume = {10},
number = {1},
year = {2019},
keywords = {},
abstract = {Background: A single-nucleotide polymorphism (SNP) of the LHPP gene (rs35936514) has been reported to be associated with major depressive disorder (MDD) in genome-wide association studies. However, the systems-level neural effects of rs35936514 that mediate the association are unknown. We hypothesized that variations in rs35936514 would be associated with structural and functional changes in gray matter (GM) at rest in MDD patients.
Methods: A total of 50 MDD patients and 113 healthy controls (HCs) were studied. Functional connectivity (FC) was analyzed by defining the bilateral hippocampus as the seed region. Voxel-based morphometry (VBM) was performed to assess the patterns of GM volume. The subjects were further divided into two groups: a CC homozygous group (CC; 24 MDD and 56 HC) and a risk T-allele carrier group (CT/ TT genotypes; 26 MDD and 57 HC). A 2×2 analysis of variance (ANOVA: diagnosis × genotype) was used to determine the interaction effects and main effect (P},
issn = {2223-4306}, url = {https://qims.amegroups.org/article/view/33175}
}