TY  - JOUR
AU  - Chen, Linglong
AU  - Li, Shenghong
AU  - Cai, Fengqin
AU  - Wu, Lin
AU  - Gong, Honghan
AU  - Pei, Chonggang
AU  - Zhou, Fuqing
AU  - Zeng, Xianjun
PY  - 2019
TI  - Altered functional connectivity density in primary angle-closure glaucoma patients at resting-state
JF  - Quantitative Imaging in Medicine and Surgery; Vol 9, No 4 (April 30, 2019): Quantitative Imaging in Medicine and Surgery
Y2  - 2019
KW  - 
N2  - Background: Primary angle-closure glaucoma (PACG) is a neurodegenerative disease. Previous structural and functional studies of functional magnetic resonance imaging (fMRI) have demonstrated widespread dysfunction of spontaneous activity in the PACG brain. In this study, we applied a data-driven graph theory approach of functional connectivity density (FCD) mapping to investigate the altered local and global functional connectivity (FC) of the cortex in PACG.  Methods: Forty-five PACG patients (53.28±10.79 years, 17 males/28 females) and 46 well-matched healthy controls (HCs) (52.67±11.01 years,18 males/28 females) received resting-state fMRI scans. All PACG patients finished complete ophthalmologic examinations, including retinal nerve fiber layer thickness (RNFLT), intraocular pressure (IOP), average cup to disc ratio (A-C/D), and vertical cup to disc ratio (V-C/D). We calculated the between-group FCD difference for short-range and long-range in each voxel. Then, we generated the intrinsic FC of the seed region with the whole brain. Finally, correlations were investigated between FCD value of the altered regions and clinical variables.  Results: PACG patients showed increased short-range FCD in the left inferior frontal gyrus (IFG)/insula/parahippocampal gyrus and right IFG/insula (P
UR  - https://qims.amegroups.org/article/view/25282