@article{QIMS22850,
author = {Xiaomei Lu and Zaiming Lu and Jiandong Yin and Yuying Gao and Xingbiao Chen and Qiyong Guo},
title = {Effects of radiation dose levels and spectral iterative reconstruction levels on the accuracy of iodine quantification and virtual monochromatic CT numbers in dual-layer spectral detector CT: an iodine phantom study},
journal = {Quantitative Imaging in Medicine and Surgery},
volume = {9},
number = {2},
year = {2018},
keywords = {},
abstract = {Background: The purpose of this study is to investigate the accuracy of iodine quantification and virtual monochromatic CT numbers obtained with the dual-layer spectral CT (DLCT) using a phantom at different radiation dose levels and spectral iterative reconstruction (IR) levels.
Methods: An abdomen phantom with seven iodine inserts (2.0, 2.5, 5.0, 7.5, 10.0, 15.0, 20.0 mg/mL) was imaged using a DLCT scanner. Five repeated scans were performed at computed tomography dose index volume (CTDIvol) levels of 5, 10, 15, 20, 25 mGy at tube voltages of 120 and 140 kVp, respectively. Spectral-based images were reconstructed using four spectral IR levels (spectral level of 0, 2, 4, 6). Iodine density images and virtual monochromatic images (VMI) at energy levels of 50, 70 and 120 keV were created. The absolute percentage bias (APB) of the measured iodine concentration and the true iodine concentration, and the measured VMI CT numbers and the theoretical VMI CT numbers were compared to determine the difference of radiation dose levels and different spectral IR levels.
Results: At CTDIvol levels of 25, 20, 15, 10 mGy, radiation dose levels had no effect on the accuracy of iodine quantitation; at CTDIvol level of 5 mGy, the accuracy of iodine quantification was the poorest, with the mean APBiodine of 4.33% (P},
issn = {2223-4306}, url = {https://qims.amegroups.org/article/view/22850}
}