@article{QIMS22068,
author = {Lei Shi and Feng-Lei Du and Zong-Wen Sun and Lan Zhang and Yuan-Yuan Chen and Tie-Ming Xie and Pei-Jing Li and Shuang Huang and Bai-Qiang Dong and Min-Ming Zhang},
title = {Radiation-induced gray matter atrophy in patients with nasopharyngeal carcinoma after intensity modulated radiotherapy: a MRI magnetic resonance imaging voxel-based morphometry study},
journal = {Quantitative Imaging in Medicine and Surgery},
volume = {8},
number = {9},
year = {2018},
keywords = {},
abstract = {Background: Gray matter (GM) damage after radiotherapy (RT) in nasopharyngeal carcinoma (NPC) patients can result in cognitive impairment, while there may be no visible brain tissue change according to the conventional magnetic resonance imaging (MRI). This study investigated radiation-induced GM volume differences between NPC patients who received RT and those who did not.
Methods: High-resolution brain structural MRI data from two groups of patients were acquired. The pre-RT group was composed of 56 newly diagnosed but not yet medically treated NPC patients, while the after-RT group consisted of 40 NPC patients who had completed RT more than 1 year ago. Voxel-based morphometry (VBM) was applied to assess GM volumes. Two sample t-test was used to analyze GM volumes voxel-by-voxel using the VBM8 toolbox built in the SPM software. Radiation-induced cortical volume alteration in all NPC patients after RT and dosimetry of 36 patients were analyzed.
Results: Compared to pre-treatment group, cortical volumes of GM were significantly smaller in the left hippocampus, the right pulvinar and the right middle temporal gyrus (MTG, P},
issn = {2223-4306}, url = {https://qims.amegroups.org/article/view/22068}
}