@article{QIMS21843,
author = {Zhifeng Liu and Qingyu Liu and Gongfa Wu and Haigang Li and Yue Wang and Rui Chen and Cai Wen and Qin Ling and Zhengfei Yang and Wanchun Tang},
title = {Quantitative CT assessment of lung injury after successful cardiopulmonary resuscitation in a porcine cardiac arrest model of different downtimes},
journal = {Quantitative Imaging in Medicine and Surgery},
volume = {8},
number = {9},
year = {2018},
keywords = {},
abstract = {Background: Utilize quantitative computed tomography (QCT) to detect and evaluate the severity of lung injury after successful cardiopulmonary resuscitation (CPR) in a porcine cardiac arrest (CA) model with different downtimes.
Methods: Twenty-one male domestic pigs weighing 38±3 kg were randomized into 3 groups: the sham group (n=5), the ventricular fibrillation (VF) 5 min (VF5) group (n=8), and the VF 10 min (VF10) group (n=8). VF was induced and untreated for 5 (VF5 group) or 10 (VF10 group) min before the commencement of manual CPR. Eight animals (8/8, 100%) in VF5 and 6 (6/8, 75%) in VF10 were successfully resuscitated. Chest QCT scans and arterial blood gas tests were performed at baseline and 6 h post-resuscitation. The QCT score, volume, and weight of ground-glass opacification (GGO), which was defined as poorly aerated regions with a CT value ranging from −500 Hounsfield units (HU) to −100 HU, and intense parenchymal opacification (IPO), which was defined as a non-aerated area with a CT value greater than −100 HU, were quantitatively measured.
Results: Significantly shorter durations of CPR and fewer defibrillations were observed in the VF5 group compared with the VF10 group [duration of CPR: VF5 (6±0 minutes) versus VF10 (8.3±1.5 minutes), P},
issn = {2223-4306}, url = {https://qims.amegroups.org/article/view/21843}
}