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Left atrial dysfunction in different morphologic phenotypes of hypertrophic cardiomyopathy: a cardiac magnetic resonance feature tracking study

   
@article{QIMS155003,
	author = {Yiyuan Gao and Wenqi Liu and Zhan Feng and Youfan Zhao and Jingjing Shi and Wanzhen Li and Zewen Qiao and Lin Tian and Yunjun Yang and Wenbo Xiao and Maosheng Xu},
	title = {Left atrial dysfunction in different morphologic phenotypes of hypertrophic cardiomyopathy: a cardiac magnetic resonance feature tracking study},
	journal = {Quantitative Imaging in Medicine and Surgery},
	volume = {16},
	number = {7},
	year = {2026},
	keywords = {},
	abstract = {Background: Hypertrophic cardiomyopathy (HCM) exhibits substantial phenotypic heterogeneity; however, differences in left atrial (LA) function among morphological subtypes remain poorly characterized. Cardiac magnetic resonance feature tracking (CMR-FT) offers advanced capabilities for quantifying LA deformation, yet its application to the evaluation of subtype-specific LA mechanics remains limited. This study aimed to investigate LA functional impairment among HCM phenotypic subtypes using CMR-FT.Methods: A total of 225 patients with HCM, divided into septal (n=153), apical (n=40), and concentric (n=32) subgroups, along with 68 age- and sex-matched healthy controls (HC), were retrospectively included from March 2023 to October 2024 at three tertiary hospitals. LA functional parameters, including reservoir strain (εs), conduit strain (εe), booster strain (εa), peak positive strain rate (SRs), peak early negative strain rate (SRe), and peak late negative strain rate (SRa), were obtained using CMR-FT. Statistical analyses included Chi-squared tests, one-way analysis of variance (ANOVA) with post hoc testing, linear regression, and intraclass correlation coefficients (ICCs).Results: All HCM subgroups showed impaired LA strain parameters compared to HC [(εs, %): septal: 26.69±11.02, apical: 23.47±8.16, concentric: 21.30±6.53 vs. control: 46.43±13.73; (εe, %): septal: 12.36±6.42, apical: 10.87±4.28, concentric: 9.72±4.28 vs. control: 27.88±11.15; (εa, %): septal: 14.34±6.41, apical: 12.60±4.97, concentric: 11.58±5.56 vs. control: 18.55±6.04; all P},
	issn = {2223-4306},	url = {https://qims.amegroups.org/article/view/155003}
}