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The value of dual-layer detector spectral CT multiparameter imaging in distinguishing between benign lesions and carcinomas of the larynx and hypopharynx

   
@article{QIMS154898,
	author = {Yu Mao and Ping Wang and Shengdan Liu and Mingling Yu and Li Han and Yue He and Lu Yang and Guangxiang Chen},
	title = {The value of dual-layer detector spectral CT multiparameter imaging in distinguishing between benign lesions and carcinomas of the larynx and hypopharynx},
	journal = {Quantitative Imaging in Medicine and Surgery},
	volume = {16},
	number = {7},
	year = {2026},
	keywords = {},
	abstract = {Background: Accurately distinguishing between benign and malignant lesions in the larynx and hypopharynx is crucial for formulating individualized and precise treatment plans. Due to the low soft-tissue resolution of conventional computed tomography (CT), the diagnostic accuracy of laryngeal and hypopharyngeal lesions is not satisfactory in clinical practice. Therefore, this study aimed to assess the value of dual-layer detector spectral computed tomography (DLSCT) multiparameter imaging for distinguishing between laryngeal and hypopharyngeal benign lesions (LHBLs) and laryngeal and hypopharyngeal carcinomas (LHCs) and to identify the optimal DLSCT parameters.Methods: The data of 141 patients were retrospectively analyzed. Spectral CT parameters, including those derived from the arterial phase (AP) and venous phase (VP), as well as the maximum lesion diameter (MLD), were measured and analyzed. The diagnostic performance of each spectral parameter was evaluated using receiver operating characteristic (ROC) curve analysis and the area under the curve (AUC). The DeLong test was then used to compare differences in diagnostic performance. The parameters demonstrating the highest AUC in the AP and VP were integrated via logistic regression. Clinical utility was assessed by decision curve analysis (DCA).Results: With the exception of the virtual non-contrast CT values in the AP and the standardized effective atomic number (sZeff) in both the VP and AP, all the measured spectral CT parameters differed significantly between the LHBLs and LHCs (P},
	issn = {2223-4306},	url = {https://qims.amegroups.org/article/view/154898}
}