@article{QIMS154750,
author = {Huanhuan Liang and Kaibo Sun and Hui Zhu and Yucan Chen and Peipei Jiang and Huanhuan Wang and Nan Zhou and Yali Hu and Zhengyang Zhou and Kefeng Zhou},
title = {Quantitative T2 mapping of junctional zone alterations in endometrial fibrosis: comparison with diffusion-weighted imaging},
journal = {Quantitative Imaging in Medicine and Surgery},
volume = {16},
number = {7},
year = {2026},
keywords = {},
abstract = {Background: Endometrial fibrosis can disrupt the uterine junctional zone and lead to infertility. Accurate and noninvasive evaluation of junctional zone alterations is important to clinical treatment. Although conventional T2-weighted imaging provides only qualitative information, quantitative techniques such as diffusion-weighted imaging (DWI) and T2 mapping may better capture fibrosis-related microstructural changes. This study aimed to use T2 mapping to quantitatively assess junctional zone alterations in endometrial fibrosis using, compare its performance with the apparent diffusion coefficient (ADC), and evaluate its diagnostic value and reproducibility.Methods: This prospective study included 86 patients with severe endometrial fibrosis (SEF), 40 patients with mild-to-moderate endometrial fibrosis (MMEF), and 55 healthy women. Junctional zone thickness (JZT), outer myometrial thickness (OMT), T2 relaxation times of the junctional zone (T2JZ) and outer myometrium (T2OM), and ADC values of the junctional zone (ADCJZ) and outer myometrium (ADCOM) were measured and analyzed. Statistical analyses included Kruskal-Wallis one-way analysis of variance, Spearman correlation analysis, binary logistic regression, receiver operating characteristic curves, and intraclass correlation coefficients.Results: JZT, T2JZ, and ADCJZ values were significantly higher in patients with SEF (6.0 mm, 81.3 ms, 1.04×10−3 mm2/s, respectively) and patients with MMEF (5.1 mm, 71.2 ms, and 0.98×10−3 mm2/s, respectively) than in healthy women (3.8 mm, 65.2 ms, and 0.81×10−3 mm2/s, respectively) (all P values },
issn = {2223-4306}, url = {https://qims.amegroups.org/article/view/154750}
}