@article{QIMS1309,
author = {Jing Yuan and Steven Kwok Keung Chow and David Ka Wai Yeung and Anil T Ahuja and Ann D King},
title = {Quantitative evaluation of dual-flip-angle T1 mapping on DCE-MRI kinetic parameter estimation in head and neck},
journal = {Quantitative Imaging in Medicine and Surgery},
volume = {2},
number = {4},
year = {2012},
keywords = {},
abstract = {Purpose: To quantitatively evaluate the kinetic parameter estimation for head and neck (HN) dynamic contrast-enhanced (DCE) MRI with dual-flip-angle (DFA) T1 mapping.
Materials and methods: Clinical DCE-MRI datasets of 23 patients with HN tumors were included in this study. T1 maps were generated based on multiple-flip-angle (MFA) method and different DFA combinations. Tofts model parameter maps of kpep, Ktrans and vp based on MFA and DFAs were calculated and compared. Fitted parameter by MFA and DFAs were quantitatively evaluated in primary tumor, salivary gland and muscle.
Results: T1 mapping deviations by DFAs produced remarkable kinetic parameter estimation deviations in head and neck tissues. In particular, the DFA of [2º, 7º] overestimated, while [7º, 12º] and [7º, 15º] underestimated Ktrans and vp, significantly (P},
issn = {2223-4306}, url = {https://qims.amegroups.org/article/view/1309}
}